Acta Limnologica Brasiliensia
https://actalb.org/article/doi/10.1590/S2179-975X7022
Acta Limnologica Brasiliensia
Original Article

Occurrence and ecological risk assessment of pharmaceutically active compounds in neotropical small basins, Brazil

Ocorrência e avaliação de risco ecológicos de compostos farmaceuticamente ativos em pequenas bacias neotropicais, Brasil

Alessandro Minillo; William Deodato Isique; Claudia Andrea Lima Cardoso; Yzel Rondon Súarez

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Abstract

Abstract: Aim: The aim of our study was to evaluate the contamination levels of selected pharmaceutically active compounds (PAC) and their potential ecological threat to forested streams.

Methods: Samples of stream water were collected in the second largest city in Mato Grosso do Sul State in center-west of Brazil. Physicochemical parameters and concentrations of PAC were quantified in samples collected in six field campaigns. Ecological risk assessment (ERA) based on risk quotient (RQ) was performed based on the maximum measured concentration of PAC in water.

Results: Six pharmaceutical compounds were successfully quantified in the forested streams, namely caffeine, naproxen, diclofenac, estriol, estradiol and ethinylestradiol. From the point of view of ecological risk, ethinylestradiol (22,57), estradiol (1,46), diclofenac (16.99) and caffeine (5.30) can be considered as priorities PAC, as they present moderate to high risks to aquatic organisms and may also cause damage to the food chain.

Conclusions: This study provides valuable information to emphasize the importance of continuous monitoring of forested streams in the west central region of the country, as well as efforts to control the input of these micropollutants into watercourses.

Keywords

pharmaceuticals, estrogens, risk assessment, environmental contaminants

Resumo

Resumo: Objetivo: O objetivo do nosso estudo foi avaliar os níveis de contaminação de compostos farmaceuticamente ativos selecionados e sua potencial ameaça ecológica em riachos florestais.


Métodos: Amostras de água de córregos foram coletadas na segunda maior cidade do estado de Mato Grosso do Sul no centro-oeste do Brasil. Parâmetros físico-químicos e concentrações de CFA foram quantificados em amostras coletadas de seis campanhas de campo. A avaliação de risco ecológico (ARE) por meio do quociente de risco (QR) foi realizada com base na concentração máxima medida de CFA na água.

Resultados: Seis compostos farmacêuticos foram quantificados com sucesso nos riachos florestais, a saber, cafeína, naproxeno, diclofenaco, estriol, estradiol e etinilestradiol. Do ponto de vista do risco ecológico, o etinilestradiol (22.57), o estradiol (1.46), o diclofenaco (16,99) e a cafeína (5,30) podem ser considerados como CFA prioritários, pois apresentaram riscos moderados a altos para os organismos aquáticos e podem levar a danos ao longo da cadeia alimentar.

Conclusões: Este estudo fornece informações valiosas para reforçar a importância do monitoramento contínuo dos córregos florestados na região centro-oeste do país, bem como os esforços para controlar a entrada desses micropoluentes nos cursos d'água.
 

Palavras-chave

fármacos, estrógenos, análise de risco, contaminantes ambientais

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Submitted date:
10/21/2022

Accepted date:
04/06/2023

Publication date:
05/23/2023

646ccd66a953952c8d2f38b6 alb Articles
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